David Goltzman Selected Research

1,25-dihydroxyvitamin D

1/2022	Inhibition of Nrf2 degradation alleviates age-related osteoporosis induced by 1,25-Dihydroxyvitamin D deficiency.
1/2022	Role of 1,25-dihydroxyvitamin D in alleviating alveolar bone loss and gingival inflammation in ligature-induced periodontitis.
1/2021	1,25-Dihydroxyvitamin D deficiency induces sarcopenia by inducing skeletal muscle cell senescence.
1/2020	1,25-Dihydroxyvitamin D insufficiency accelerates age-related bone loss by increasing oxidative stress and cell senescence.
1/2020	1,25-Dihydroxyvitamin D protects against age-related osteoporosis by a novel VDR-Ezh2-p16 signal axis.
1/2018	1,25-dihydroxyvitamin D deficiency accelerates alveolar bone loss independent of aging and extracellular calcium and phosphorus.
1/2017	Fibroblast Growth Factor 23 Regulation by Systemic and Local Osteoblast-Synthesized 1,25-Dihydroxyvitamin D.
7/2012	Bone marrow ablation demonstrates that excess endogenous parathyroid hormone plays distinct roles in trabecular and cortical bone.
8/2010	Emerging roles for calcium-regulating hormones beyond osteolysis.
3/2010	Vitamin D action : Lessons learned from genetic mouse models.

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David Goltzman Research Topics

Disease

25	Osteoporosis 01/2022 - 03/2004
24	Bone Resorption 05/2022 - 04/2002
14	Neoplasms (Cancer) 12/2021 - 03/2003
11	Hypercalcemia (Milk Alkali Syndrome) 12/2021 - 03/2003
9	Hypocalcemia 01/2018 - 04/2004
8	Secondary Hyperparathyroidism 01/2017 - 03/2003
8	Hypophosphatemia 12/2013 - 12/2002
7	Rickets (Rachitis) 01/2021 - 03/2003
6	Hypoparathyroidism 02/2022 - 04/2004
5	Hyperparathyroidism 02/2022 - 10/2007
5	Osteomalacia 01/2021 - 03/2003
5	Chronic Renal Insufficiency 11/2019 - 03/2004
3	Inflammation (Inflammations) 01/2022 - 01/2013
3	Neoplasm Metastasis (Metastasis) 12/2021 - 09/2004
3	Familial Hypophosphatemic Rickets (X-Linked Hypophosphatemia) 01/2021 - 12/2002
3	Osteolysis 01/2019 - 07/2006
3	Body Weight (Weight, Body) 01/2016 - 11/2015
3	Vitamin D Deficiency 12/2015 - 12/2010
2	Alveolar Bone Loss 01/2022 - 01/2018
2	Lymphoma (Lymphomas) 01/2020 - 01/2019
2	Carcinogenesis 01/2018 - 01/2013
2	Metabolic Bone Diseases (Osteopenia) 06/2017 - 11/2011
2	Coronary Artery Disease (Coronary Atherosclerosis) 08/2016 - 10/2014
2	Insulin Resistance 04/2016 - 10/2004
2	Multiple Sclerosis 03/2016 - 08/2015
2	Psoriasis (Pustulosis Palmaris et Plantaris) 02/2016 - 03/2004
2	Infertility (Sterility) 01/2015 - 12/2010
2	Type 2 Diabetes Mellitus (MODY) 10/2014 - 10/2004
2	Primary Hyperparathyroidism 04/2012 - 04/2005
2	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 12/2011 - 10/2010
2	Hyperplasia 09/2011 - 03/2003
2	Hypertrophy 03/2010 - 01/2004
2	Prostatic Neoplasms (Prostate Cancer) 07/2006 - 03/2003
2	Tetany (Spasmophilia) 10/2005 - 06/2005
1	Parathyroid Neoplasms (Parathyroid Neoplasm) 02/2022
1	Periodontitis 01/2022
1	Cognitive Dysfunction 01/2022
1	Chronic Pancreatitis 10/2021
1	Infantile Hypercalcemia 01/2021
1	Sarcopenia 01/2021
1	Multiple Myeloma 01/2019
1	Multiple Endocrine Neoplasia Type 2a (MEN 2) 01/2019
1	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2019
1	Acromegaly 01/2019
1	Hyperthyroidism 01/2019

Drug/Important Bio-Agent (IBA)

25	CalciumIBA 01/2019 - 03/2003
23	Vitamin D FDA LinkGeneric 01/2021 - 12/2002
22	hydroxide ionIBA 01/2022 - 05/2004
20	1,25-dihydroxyvitamin DIBA 01/2022 - 03/2003
18	Parathyroid Hormone-Related ProteinIBA 12/2021 - 05/2002
17	Parathyroid Hormone (Parathormone)IBA 01/2019 - 03/2004
10	Calcitriol (Calcijex)FDA LinkGeneric 01/2022 - 03/2004
9	25-Hydroxyvitamin D3 1-alpha-Hydroxylase (25 Hydroxyvitamin D3 1 alpha Hydroxylase)IBA 01/2021 - 05/2004
8	Phosphorus (Red Phosphorus)IBA 01/2018 - 10/2010
7	CytokinesIBA 01/2022 - 07/2006
7	Proteins (Proteins, Gene)FDA Link 01/2020 - 08/2004
7	Phosphates (Orthophosphate)IBA 01/2018 - 12/2002
6	Calcium-Sensing ReceptorsIBA 10/2021 - 07/2007
6	25-hydroxyvitamin DIBA 01/2020 - 04/2004
6	Hormones (Hormone)IBA 01/2019 - 09/2004
6	Fibroblast Growth Factor-23IBA 01/2017 - 03/2003
4	Messenger RNA (mRNA)IBA 05/2022 - 08/2004
4	DNA (Deoxyribonucleic Acid)IBA 02/2022 - 11/2010
4	Pharmaceutical PreparationsIBA 01/2019 - 09/2012
4	MineralsIBA 01/2018 - 04/2014
3	OsteoprotegerinIBA 05/2022 - 07/2006
3	Alkaline PhosphataseIBA 01/2022 - 07/2012
3	EnzymesIBA 01/2020 - 05/2004
3	Biological ProductsIBA 01/2018 - 03/2003
3	Glucose (Dextrose)FDA LinkGeneric 06/2017 - 10/2014
3	Insulin (Novolin)FDA Link 04/2016 - 10/2004
3	AndrogensIBA 12/2015 - 03/2003
3	Mixed Function Oxygenases (Monooxygenases)IBA 01/2015 - 04/2004
2	LigandsIBA 05/2022 - 07/2006
2	Transcription Factors (Transcription Factor)IBA 02/2022 - 11/2012
2	Collagen Type I (Type I Collagen)IBA 01/2022 - 07/2012
2	Adenine FDA LinkGeneric 11/2019 - 01/2017
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2019 - 01/2019
2	AntioxidantsIBA 01/2018 - 02/2015
2	OsteocalcinIBA 06/2017 - 08/2008
2	Small Interfering RNA (siRNA)IBA 01/2016 - 01/2013
2	CholesterolIBA 12/2015 - 12/2011
2	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2013 - 05/2004
2	LDL Receptors (LDL Receptor)IBA 12/2011 - 10/2010
2	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 08/2010 - 04/2005
2	Prostate-Specific Antigen (Semenogelase)IBA 07/2006 - 09/2004
2	Cytoplasmic and Nuclear Receptors (Nuclear Receptors)IBA 10/2004 - 05/2004
2	Androgen Receptors (Androgen Receptor)IBA 09/2004 - 03/2003
1	oltiprazIBA 01/2022
1	Cholinergic Antagonists (Anticholinergics)IBA 01/2022
1	Indicators and Reagents (Reagents)IBA 01/2022
1	Sirtuin 1IBA 01/2020
1	Urea (Carbamide)FDA LinkGeneric 11/2019
1	NitrogenIBA 11/2019
1	Vitamin A (Retinol)FDA LinkGeneric 01/2019
1	Foscarnet FDA LinkGeneric 01/2019
1	LithiumIBA 01/2019

Therapy/Procedure

7	Therapeutics 01/2019 - 07/2006
1	Ligation 01/2022
1	Parenteral Nutrition 01/2019